General comments:In my opinion, it is valuable to investigate coupled interactions between the terrestrial carbon cycle, atmospheric chemistry, and climate change in regional scale. The manuscript entitled: " The Regional Climate-Chemistry-Ecology  Coupling Model RegCM-Chem (v4.6)-YIBs (v1.0): Development and Application " presents valuable results which merit publication in egusphere  after minor corrections. There are comments I suggest the authors should take into account:

In 3.2 Climate simulations in East Asian，the representativeness of statistical indicators for comparison between model simulation results and reanalysis data is not clear. The author did not provide the temporal resolution of statistical indicators such as Correlation coefficients (R), mean biases (MB), and root mean square error (RMSE).

This work built a new framework that couples terrestrial biosphere model and regional climate model. It is a novel and important investigation to explore the interaction between plants and climate change. Although the new model was evaluated using multi source data which showed a nice comparison, I think you should evaluate the ability of couple model through comparing the model results between couple and independent model (either biogenic model or climate model). We need to see if the coupled model works better than independent model. If so, how better? What is the dominant mechanism to improve the model perform through coupling? In addition, the description of couple method is not enough detail to help reader to understand this work. For example, meteorological variables and atmospheric pollutant concentrations generated by RegCM-Chem are incorporated into the YIBs model every six-minute intervals. Why do you determine the interval of six minutes? Another example, outputs from the YIBs are subsequently integrated back into the RegCM-Chem model, modulating atmospheric composition and atmospheric variables. How often do those outputs integrate back? How can these outputs from YIBs model change the atmospheric variables? Directly or indirectly?  How do you calculate the biogenic VOC emission flux, which is needed to state briefly although it was described in reference.