DECIPHeR (Dynamic fluxEs and ConnectIvity for Predictions of Hydrology) is a new modelling framework that can be applied from small catchment to continental scales for complex river basins. This paper describes the modelling framework and its key components and demonstrates the model’s ability to be applied across a large model domain. This work highlights the potential for catchment- to continental-scale predictions of streamflow to support robust environmental management and policy decisions.